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Optimal Pedigree Types

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First, let us provide definitions of some key genetic terms used in describing various types of pedigrees (the terms below are used for recessively inherited diseases):

Clear This indicates a dog which does not have the disease gene present.

Carrier This indicates a dog which has one disease gene and one normal gene but the dog itself may not exhibit any signs of disease.

Affected This indicates a dog which will -- or currently does -- show signs of the disease because it has two disease genes.

img00001.gif (860 bytes)This symbol indicates a female.

img00002.gif (851 bytes)This symbol indicates a male.

img00002.gif (851 bytes)or img00001.gif (860 bytes)These symbols indicate either clear or carrier dogs.

img00005.gif (838 bytes)or img00006.gif (847 bytes)These symbols indicate affected dogs.


Recessive Inheritance This means that a dog must have two disease genes in order to be affected with the disease.


Dominant Inheritance This means that the dog will be affected with only one copy of the disease gene.



bulletIn all cases, collected samples are most informative if there are at least two offspring (either brothers and sisters or half-brothers and sisters) affected with the disease.
bulletWhile the sex of affected animals is indicated in the pedigrees listed below, sex of the animals is irrelevant to our research.
bulletPedigrees with more than one known affected dog are useful even if a sample is available from only one affected dog.
bulletSamples from unaffected offspring are less useful than samples from affected offspring but should be collected when available. These samples are important especially when the parents are not available for sample collection.

VetGen is looking for pedigrees where there is a presence of a Genetic Disease which is part of our current research program.

The following are examples of pedigrees that would be useful for our research in trying to locate disease genes.


Pedigree Example Number 1:

In this example:

bulletboth parents would be carriers
bullettheir offspring would include at least 2 affected


We would be interested in samples from:

bulletthe affected offspring
bullettheir parents
bulletthe siblings of the affected offspring

img00007.gif (1604 bytes)


Pedigree Example Number 2:

In this pedigree:

bullettwo (or more) bitches were bred to the same stud dog or a bitch was bred to more than one stud dog
bulletaffected dogs showed up in these different litters

We would be interested in samples from:

bulletaffected dogs are half-brothers or sisters
bulletany affected offspring
bulletall three of the parents
bulletother siblings from any of the litters

img00008.gif (1707 bytes)


Pedigree Example Number 3:

In this pedigree:

bulletone of the parents is affected with the disease
bulletoffspring would include at least two affected dogs

We would be interested in samples from:

bulletthe affected offspring
bulletboth of the parents
bulletother available offspring

img00009.gif (1353 bytes)


Pedigree Example Number 4:

In this example:

bullettwo or more affected siblings are available
bullettheir parents are not

We would be interested in samples from:

bulletthe affected dogs
bulletunaffected siblings where available

img00010.gif (1150 bytes)


Pedigree Example Number 5:

In this example:

bulletan affected has been used in several different breedings
bulletone or more affected offspring are available from different breedings

We would be interested in samples from:

bulletthe affected offspring
bulletsiblings of the affected
bulletimg00011.gif (1538 bytes)

Dog lovers who have useful pedigrees and are interested in helping VetGen's research should contact:
Our Research Department, either through e-mail: HealthyDog@VetGen.com; or by calling
VetGen at (734)669-8440 or 1-800-4-VETGEN; or by faxing at (734)669-8441.
If you write an e-mail message or fax please include a phone number and time that you can normally be reached.

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This page site is greatly donated by VetGen.  
All material on this and all linked pages is Copyright 1997-2004.
With permission by VetGen Research Department.







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